A simple model for the kinetics of packaging of DNA in to a capsid against an external force

We propose a simple model for the kinetics of packaging of viral DNA in to a capsid against an external force trying to prevent it. The model leads to a Butler-Volmer type dependence of the rate of packaging on the pulling force F

Forward to Fundamental Alteration: Addressing ADA Title II Integration Lawsuits after Olmstead v. L. C

In 1999, the Supreme Court reviewed the case of Olmstead v. L.C. by Zimring, which has been called the Brown v. Board of Education for the law of disability discrimination. The Court ultimately agreed with the Department of Justice ( DOJ ) and held that the Americans with Disabilities Act ( ADA ), along with its supplementary Integration Regulation, requires a State that offers treatment to persons with disabilities to provide such treatment in a community setting where such a placement would not be an unreasonable change or a fundamental alteration in the State\u27s program. Advocates of community care have long argued that such care is superior to institutionalized care in cost, treatment success, and equity. The ADA is the latest in a long line of legal avenues whereby advocates of disability rights have attempted to fashion some right to community care for developmentally disabled and mentally ill people. Opponents argue that the application of the Integration Regulation adopted by courts and the Department of Justice is beyond the reach of the ADA, which is limited to situations of uneven treatment as between disabled and non-disabled individuals. Left open by the current debate, and by the opinions interpreting the relevant provisions of the ADA, is what measures might constitute unreasonable modifications or fundamental alterations such that the ADA would not require them. This paper argues initially that (1) legislative history, (2) traditional deference for implementing regulations, (3) the weight of the pre-L.C. case law in the lower courts, and (4) public choice limitations on state power centers all suggest that the Supreme Court correctly held that the Integration Regulation does indeed apply to unnecessarily institutionalized individuals. However, state actors, advocates, and judges are still left without a well-developed list of arguments for whether and to what extent a proposed modification might be deemed unreasonable or a fundamental alteration such that the ADA Title II would not require it. The Supreme Court expressly called for limits to the application of the Integration Regulation and ADA Title II, and well articulated limits have yet to be developed. Thus, the bulk of the paper addresses and puts within an intellectual framework the arguments available to advocates and decision-makers attempting to keep ADA Title II within manageable bounds. The paper first addresses program integrity arguments in the context of each of three ideal types, i.e., three general categories of cases. Then the paper addresses magnitude arguments that could apply to all three types of cases

Maternal booking status as a criterion for admission for neonatal intensive care

No Abstract

Discovering predictive variables when evolving cognitive models

A non-dominated sorting genetic algorithm is used to evolve models of learning from different theories for multiple tasks. Correlation analysis is performed to identify parameters which affect performance on specific tasks; these are the predictive variables. Mutation is biased so that changes to parameter values tend to preserve values within the population's current range. Experimental results show that optimal models are evolved, and also that uncovering predictive variables is beneficial in improving the rate of convergence

Geophysical Exploration of Vesta

Dawn’s year-long stay at Vesta allows comprehensive mapping of the shape, topography, geology, mineralogy, elemental abundances, and gravity field using it’s three instruments and highprecision spacecraft navigation. In the current Low Altitude Mapping Orbit (LAMO), tracking data is being acquired to develop a gravity field expected to be accurate to degree and order ~20 [1, 2]. Multi-angle imaging in the Survey and High Altitude Mapping Orbit (HAMO) has provided adequate stereo coverage to develop a shape model accurate to ~10 m at 100 m horizontal spatial resolution. Accurate mass determination combined with the shape yields a more precise value of bulk density, albeit with some uncertainty resulting from the unmeasured seasonally-dark north polar region. The shape and gravity of Vesta can be used to infer the interior density structure and investigate the nature of the crust, informing models for Vesta’s formation and evolution